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Tumors use numerous mechanisms to escape detection and killing by the immune system. Results from OCRF-funded research, reported May 4, 2014 in the prestigious journal��Nature Medicine, show that ovarian cancer cells (and others) establish a protective barrier that prevents anti-tumor immune responses by using tumor-associated blood vessels to kill immune cells. ��Understanding how this process works is important since ovarian cancer outcomes are directly connected to the infiltration of disease-fighting immune cells (T cells). This finding provides a new understanding how tumors resist infiltration, and provides new therapeutic strategies to overcome this barrier.

Former OCRF Ann Schreiber Mentored Investigator Awardee����was first author on the paper; OCRF grantee and former Scientific Advisory Committee member����was senior author of the paper.

“This work could not have been completed without the support of OCRF and its donors,” said Dr. Motz. ��“We are grateful for all of OCRF’s hard work and efforts.”

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